Twist-on connectors are not often used on wire gauges thicker than AWG #10 (5.26 mm²), because such solid wires are too stiff to be reliably connected with this method. They are commonly used as an alternative to terminal blocks or the soldering of conductors together, since they are quicker to install and, unlike soldered or crimped connections, allow easy subsequent removal for future modifications. Twist-on wire connectors are commonly color-coded to indicate the connector size and, hence, their capacity. Such extensions also allow these connectors to be installed with a common nut driver or a specialized tool. Winglike extensions are commonly molded into higher quality connectors to reduce operator muscle fatigue when installing a large number of the connectors. They may have external grooves to make them easier to handle and apply. Twist-on wire connectors are typically installed by hand. Electrical continuity is maintained by both the direct twisted wire-to-wire contact and by contact with the metal insert. When such a connector is twisted onto the stripped ends of wires, the wires are drawn into the connector's metal insert and squeezed together inside it.

While their exterior covering is typically made from insulating plastic, their means of connection is a tapered coiled metal insert, which threads onto the wires and holds them securely. Twist-on wire connectors are available in a variety of sizes and shapes.

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